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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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C. Recreational Drugs and Alcohol

Cialis (tadalafil) can interact with recreational drugs and alcohol that treat blood pressure, potentially increasing the risk of adverse effects. Here are the key drug- Recreational Drugs and Alcohol:

  1. Rifampicin:razilner guinea pig retina toxicity
  2. Cenataphanax: Acesiantine toxicity
  3. Nitroglycerin: Impaired blood levels of nitroglycerin by inhibiting cyclic guanosine monophosphate (cGMP)-* kinase
  4. Nitrofurantoin: Increased effectiveness of the two medications with rifampicin.
  5. Cefadoxyscinomycin: Increased effectiveness of the two medications with cypenafadoxyscinomycin.

D.

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Sildenafil Citrate In India comes in different strengths, including 25 mg, 50 mg, 100 mg, and 150 mg. The recommended starting dose for Sildenafil Citrate In India is 100 mg, taken 1 hour before sexual activity, but can be taken up to 4 hours before sexual activity. The effects of Sildenafil Citrate In India are long-lasting and can last for up to 36 hours.

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The recommended starting dose for Sildenafil Citrate In India is 25 mg, taken 1 hour before sexual activity, but can be taken up to 4 hours before sexual activity.

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Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

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  • Take one 5mg tablet once daily
  • Swallow the tablet whole
  • Take one tablet with water
  • May take 2 to 3 consecutive days for optimal results
  • Take no more than 3 consecutive days for optimal results
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Report any new or worsening symptoms to your doctor immediately. You may need immediate medical attention.

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Take Tadalafil dosage orally, either with or without food, as directed by your healthcare provider. Tadalafil dosage should not exceed more than once a day. Swallow the tablet whole. Do not split it or crush unless advised.

Your daily dosage will depend on your medical condition, how you respond to medications, and any other medications you currently take. Before you take ED treatment pills, ensure that you inform your healthcare service provider of any prescription drugs, over-the-counter medicines, and any other supplements you take.

If you are also using finasteride alongside Tadalafil to treat any symptoms of benign prostatic hyperplasia (BPH), discuss the duration of treatment and dosage you will need with your healthcare provider.

For erectile dysfunction (ED), tadalafil citrate may be prescribed in two ways:

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Follow your doctors instructions carefully based on your specific needs and condition.

If you are using tadalafil citrate medication for ED dysfunction and BPH, take it daily as directed by your doctor. To ensure you do not forget, take it at the same time each day.

Keep your healthcare practitioner informed if your medical condition does not improve or worsens during treatment.

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Tadalafil dosage will influence your metabolism, blood pressure control, and sexual desire, therefore making sexual activity more enjoyable and reliable. To achieve the best treatment results, you should take Tadalafil dosage orally with or without food, at least one hour before a meal.

To maximize the effects of generic tadalafil, take it consistently at least 1 hour before you eat or drink a glass of water.

To avoid early loss of sexual desire, take your daily dose at the same time each day to ensure you get the best benefit from the medication.

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Common side effects:

  • Headache with or without an headache
  • Muscle aches with or without an headache
  • Vaginal pain or rash
  • Skin rash or exfoliation
  • Unusual thoughts or changes in vision
  • Chest pain or irregular heartbeat
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